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PerkinElmer - NET1039050UC - Citalopram, [N-Methyl-3H]-, 50µCi (1.85MBq)

PerkinElmer - NET1039050UC - Citalopram, [N-Methyl-3H]-, 50µCi (1.85MBq)
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10211476
NET1039050UC

PerkinElmer - NET1039050UC - Citalopram, [N-Methyl-3H]-, 50µCi (1.85MBq)

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$1,310.94

Citalopram, tritiated at the N-methyl group. Citalopram is a selective serotonin reuptake inhibitor (SSRI) antidpressant drug, and has been shown to block the serotonin transporter (SERT, 5-HTT). Citalopram (Celexa, Cipramil) is a selective serotonin reuptake inhibitor (SSRI) that blocks the serotonin transporter (SERT, 5-HTT). Citalopram is used to treat panic disorder as well as obsessive-compulsive disorder. We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays. Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments. References for NET1039: Pamela R. Tsuruda, Joey Yung, William J. Martin, Ray Chang, Ngoc Mai, Jacqueline A.M. Smith, Influence of ligand binding kinetics on functional inhibition of human recombinant serotonin and norepinephrine transporters, In Journal of Pharmacological and Toxicological Methods, Volume 61, Issue 2, 2010, Pages 192-204. Assié, M.-B. and Koek, W. [3H]-8-OH-DPAT binding in the rat brain raphe area: involvement of 5-HT1A and non-5-HT1A receptors. British Journal of Pharmacology, Volume 130, 2000, Pages 1348-1352.

See other products in some related categories (click to browse):
Detection Method: Radiometric Label Position: Specifically Labeled Product Brand Name: NEN Radiochemicals Radioisotope: H-3 Radionuclide: 3H Receptor Type: Serotonin Shipping Condition: Dry Ice Special Ordering Information: This is a radioactive product - shipping address must have a license to receive radioactive materials. Therapeutic Area: CNS & Neurologic Unit Size: 50 µCi


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