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PerkinElmer - NET1025050UC - Substance-P (9-Sar, 11-Met(O2)), [2-Prolyl-3, 4-3H]-, 50µCi (1.85MBq)

PerkinElmer - NET1025050UC - Substance-P (9-Sar, 11-Met(O2)), [2-Prolyl-3, 4-3H]-, 50µCi (1.85MBq)
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10211470
NET1025050UC

PerkinElmer - NET1025050UC - Substance-P (9-Sar, 11-Met(O2)), [2-Prolyl-3, 4-3H]-, 50µCi (1.85MBq)

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Substance-P, tritiated on the 2-prolyl group. Substance-P acts as an antagonist at neurokinin-1 receptors (NK1Rs). Substance-P acts as an antagonist at neurokinin-1 receptors, and is used to treat depression. Neurokinin receptors play a role in neuroinflammation in infection and neurodegenerative diseases. We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays. Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments. References for NET1025: Singewald, N., Chicchi, G. G., Thurner, C. C., Tsao, K.-L., Spetea, M., Schmidhammer, H., Sreepathi, H. K., Ferraguti, F., Singewald, G. M. and Ebner, K. (2008), Modulation of basal and stress-induced amygdaloid substance P release by the potent and selective NK1 receptor antagonist L-822429. Journal of Neurochemistry, 106: 2476-2488. Mantyh, P.W., Pinnock, R.D., Downes, D.P., Goedert, M., Hunt, S.P. (1984), Correlation between inositol phospholipid hydrolysis and substance P receptors in rat CNS. Nature, 309: 795-797.

See other products in some related categories (click to browse):
Detection Method: Radiometric Label Position: Specifically Labeled Molecular Weight: 1392.7 Product Brand Name: NEN Radiochemicals Radioisotope: H-3 Radionuclide: 3H Receptor Type: Tachykinin Shipping Condition: Dry Ice Special Ordering Information: This is a radioactive product - shipping address must have a license to receive radioactive materials. Therapeutic Area: CNS & Neurologic, Cardiovascular, Gastrointestinal Unit Size: 50 µCi


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