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PerkinElmer - NET1024250UC - Glibenclamide, Glyburide, [Cyclohexyl-2, 3-3H(N)]-, 250µCi (9.25MBq)

PerkinElmer - NET1024250UC - Glibenclamide, Glyburide, [Cyclohexyl-2, 3-3H(N)]-, 250µCi (9.25MBq)
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10211469
NET1024250UC

PerkinElmer - NET1024250UC - Glibenclamide, Glyburide, [Cyclohexyl-2, 3-3H(N)]-, 250µCi (9.25MBq)

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Glibenclamide (glyburide) tritiated at the cyclohexyl-2, 3 position. Glibenclamide is an antidiabetic drug that binds and inhibits the ATP-sensitive potassium channel. Glibenclamide acts as an antagonist at the thromboxane A2 receptor and at ATP-sensitive K + channels. We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays. Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments. References for NET1024: Bernardi H., Lazdunski M. (1993) Characterization of the Sulfonylurea-Sensitive ATP-Modulated Potassium Channel. In: Glossmann H., Striessnig J. (eds) Methods in Pharmacology. Springer, Boston, MA. Eiki J, Saeki K, Nagano N, Iino T, Yonemoto M, Takayenoki-Iino Y, Ito S, Nishimura T, Sato Y, Bamba Met al. 2009, A selective small molecule glucagon-like peptide-1 secretagogue acting via depolarization-coupled Ca (2+) influx. Journal of Endocrinology .

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Concentration: 1.0 - 10 mCi/mL Detection Method: Radiometric Label Position: Nominally Labeled Molecular Weight: 494.0 Radioisotope: H-3 Radionuclide: 3H Receptor Type: Potassium Shipping Condition: Dry Ice Special Ordering Information: This is a radioactive product - shipping address must have a license to receive radioactive materials. Therapeutic Area: CNS & Neurologic Unit Size: 250 µCi


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