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PerkinElmer - AL544C - IL-17A (mouse/rat) AlphaLISA Biotin-free Detection Kit, 500 Assay Points

PerkinElmer - AL544C - IL-17A (mouse/rat) AlphaLISA Biotin-free Detection Kit, 500 Assay Points
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10206744
AL544C

PerkinElmer - AL544C - IL-17A (mouse/rat) AlphaLISA Biotin-free Detection Kit, 500 Assay Points

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$1,797.10

The AlphaLISA Mouse/Rat IL-17A Biotin-Free Detection Kit is designed for the quantitative detection of mouse or rat IL-17 (IL-17A) in serum, cell culture medium, and other samples types using a homogeneous (no wash steps, no separation steps) assay. The biotin-free kit uses anti-DIG (anti-Digoxin) Donor beads instead of streptavidin Donor beads, which makes the kit compatible with high-biotin culture media and other sample types that contain high levels biotin (including brain/liver tissue extracts, milk and eggs). Formats: Our HV (high volume) 100 assay point kit allows you to run 100 wells in 96-well format, using a 100 µL reaction volume (10 µL of sample). Our 500 assay point kit allows you to run 500 wells in 96-well or 384-well format, using a 50 µL reaction volume (5 µL of sample). Our 5, 000 assay point kit allows you to run 5, 000 wells in 96-well or 384-well format, using a 50 µL reaction volume (5 µL of sample). Features: No-wash steps, no separation steps Compatible with high biotin samples, including RPMI and high-biotin tissue extracts ELISA alternative technology Sensitive detection Broad sample compatibility Small sample volume Results in less than 3 hours Half the time of an ELISA assay Interleukin 17A (IL17A) is the founding member of a group of cytokines called the IL17 family. The other members are IL17B, C, D, E, and F. Mature mouse or rat IL17A is a glycosylated homodimer formed of two 133 amino acid subunits. IL17A is produced by a subset of T helper cells. It is a proinflammatory cytokine that enhances T cell priming and stimulates macrophages, fibroblasts, endothelial and epithelial cells to produce mediators of inflammation like IL1, IL6, and TNFα. It is also critical for neutrophil activation and migration, and induces IL8, a key chemokine for neutrophils. IL17 has been involved in the proinflammatory patterns associated with joint inflammation and rheumatoid arthritis in mouse and human models and may be a novel therapeutic target for the treatment of these diseases. AlphaLISA technology allows the detection of molecules of interest in a no-wash, highly sensitive, quantitative assay. In an AlphaLISA biotin-free assay, a DIG-labeled anti-analyte antibody binds to the anti-DIG-coated Donor beads while another anti-analyte antibody is conjugated to AlphaLISA Acceptor beads. In the presence of the analyte, the beads come into close proximity. The excitation of the Donor beads causes the release of singlet oxygen molecules that triggers a cascade of energy transfer in the Acceptor beads, resulting in a sharp peak of light emission at 615 nm.

See other products in some related categories (click to browse):
Assay Target: IL17A Assay Target Class: Cytokine Automation Compatible: Yes Detection Method: Alpha Experimental Type: In vitro Product Brand Name: AlphaLISA Shipping Condition: Blue Ice Target Species: Mouse Therapeutic Area: Inflammation Unit Size: 500 assay points


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