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PerkinElmer - AL503F - IL-1 (mouse) AlphaLISA Detection Kit, 5, 000 Assay Points

PerkinElmer - AL503F - IL-1 (mouse) AlphaLISA Detection Kit, 5, 000 Assay Points
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10206600
AL503F

PerkinElmer - AL503F - IL-1 (mouse) AlphaLISA Detection Kit, 5, 000 Assay Points

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The AlphaLISA Mouse Interleukin-1ß (IL-1ß) Detection Kit is designed for detection and quantitation of mouse IL-1ß in serum, buffered solution or cell culture medium in a homogeneous (no-wash steps, no separation steps) assay. Formats: Our 500 assay point kit allows you to run 500 wells in 96-well or 384-well format, using a 50 µL reaction volume (5 µL of sample). Our 5, 000 assay point kit allows you to run 5, 000 wells in 96-well or 384-well format, using a 50 µL reaction volume (5 µL of sample). Features: No-wash steps, no separation steps ELISA alternative technology Sensitive detection Broad sample compatibility Small sample volume Results in less than 3 hours Half the time of an ELISA assay The mouse Interleukin 1 beta (IL1ß) is produced as a 269 amino acid precursor that matures by proteolysis to its 152 amino acid active form. In humans, IL1a and IL1ß are central players of the immune response, displaying roles in inflammation both at local and systemic levels. IL1ß is functionally equivalent to IL1a. Its production has been reported in many cell types including brain cells, as well as monocytic and peripheral blood mononuclear cells. Among the biological activities of IL1 is the stimulation of T-helper cells, which then secrete IL2 and express IL2 receptor. IL1 acts directly on B-cells, promoting their proliferation and the synthesis of immunoglobulins. It supports tumor cytotoxicity mediated by monocytes and induces tumor regression. It has been shown that IL1 also promotes wound healing. AlphaLISA technology allows the detection of molecules of interest in a no-wash, highly sensitive, quantitative assay. In an AlphaLISA assay, a biotinylated anti-analyte antibody binds to the Streptavidin-coated Donor beads while another anti-analyte antibody is conjugated to AlphaLISA Acceptor beads. In the presence of the analyte, the beads come into close proximity. The excitation of the Donor beads causes the release of singlet oxygen molecules that triggers a cascade of energy transfer in the Acceptor beads, resulting in a sharp peak of light emission at 615 nm.

See other products in some related categories (click to browse):
Assay Target: IL1β Assay Target Class: Cytokine Automation Compatible: Yes Detection Method: Alpha Experimental Type: In vitro Product Brand Name: AlphaLISA Shipping Condition: Blue Ice Target Species: Mouse Therapeutic Area: Inflammation Unit Size: 5, 000 assay points


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