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AdipoGen - 40B0041AAC500 - IL-33 (mouse) (rec.) (BULK) (Each (500µG))

AdipoGen - 40B0041AAC500 - IL-33 (mouse) (rec.) (BULK) (Each (500µG))
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6167209
40B0041AAC500

AdipoGen - 40B0041AAC500 - IL-33 (mouse) (rec.) (BULK) (Each (500µG))

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Interleukin-33 (IL-33; HF-NEV; IL-1F11), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released upon cell lysis. IL33 binds to and signals through ST2 (IL1R1) and its stimulation recruits MYD88, IRAK, IRAK4, and TRAF6, followed by phosphorylation of ERK1(MAPK3)/ERK2(MAPK1), p38(MAPK14), and JNK. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells, and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy & anaphylaxis, cardiovascular disease/atherosclerosis, nervous system diseases, and sepsis.

This listing is for Each (500µG)

See other products in some related categories (click to browse):
Host E. coli Form Frozen liquid. Size 500 µg Unit Each (500µG) Biological Activity Activates ST2-dependent NF-kappaB pathway. Clonality Protein Concentration Please inquire. Long Term Storage -20°C Molecular Weight ~18kDa Purity >95% (SDS-PAGE) Sequence Mouse IL-33 (aa 109-266) is untagged. Short Term Storage -20°C Species Crossreactivity Human , Mouse Specificity Binds to mouse and human ST2. Stability Stable for at least 6 months after receipt when stored at -20°C. Storage Buffer Frozen Contains PBS.


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